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Article

Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?

29 Jun 2018

Abstract excerpt

The PTEN gene encodes for the phosphatase and tensin homolog; it is a tumour suppressor gene that is among the most frequently inactivated genes throughout the human cancer spectrum. The most recent sequencing approaches have allowed the identification of PTEN genomic alterations, including deletion, mutation, or rearrangement in about 50% of prostate cancer (PCa) cases. It appears that mechanisms leading to PTEN...

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Identifiers

PMID: 30009155
DOI: 10.3389/fonc.2018.00246

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