Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical implications of PTEN loss in prostate cancer.

Nature reviews. Urology - 1 Apr 2018

Jamaspishvili Tamara, Berman David M, Ross Ashley E, Scher Howard I, De Marzo Angelo M, Squire Jeremy A, Lotan Tamara L

Abstract excerpt

Genomic aberrations of the PTEN tumour suppressor gene are among the most common in prostate cancer. Inactivation of PTEN by deletion or mutation is identified in ∼20% of primary prostate tumour samples at radical prostatectomy and in as many as 50% of castration-resistant tumours. Loss of phosphatase and tensin homologue (PTEN) function leads to activation of the PI3K-AKT (phosphoinositide 3-kinase-RAC-alpha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to DNA, Neoplasm
Share to Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Prostatic Neoplasms

Share to PTEN Phosphohydrolase

Share to Signal Transduction

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 29460925
DOI: 10.1038/nrurol.2018.9
PMCID: PMC7472658

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical implications of PTEN loss in prostate cancer.PMID 29460925Read ↗

The PTEN Conundrum: How to Target PTEN-Deficient Prostate CancerSemantic proximity Read ↗

Prostate cancer, PI3K, PTEN and prognosis.Semantic proximity Read ↗

PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer PatientsSemantic proximity Read ↗

PTEN loss detection in prostate cancer: comparison of PTEN immunohistochemistry and PTEN FISH in a large retrospective prostatectomy cohortSemantic proximity Read ↗

Transcriptional landscape of PTEN loss in primary prostate cancerSemantic proximity Read ↗

Genomic Rearrangements of PTEN in Prostate CancerSemantic proximity Read ↗

PTEN loss is associated with prostate cancer recurrence and alterations in tumor DNA methylation profilesSemantic proximity Read ↗

Therapeutic targeting of cancers with loss of PTEN function.Semantic proximity Read ↗

Transcriptional landscape of PTEN loss in primary prostate cancerSemantic proximity Read ↗

Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?Semantic proximity Read ↗

The TGF-β, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancerSemantic proximity Read ↗

The association of Phosphatase and tensin homolog (PTEN) deletion and prostate cancer risk: A meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.