Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer.

doi:10.1016/j.ajpath.2012.04.026

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Article

Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer.

The American journal of pathology - 1 Aug 2012

Krohn Antje, Diedler Tobias, Burkhardt Lia, Mayer Pascale-Sophie, De Silva Colin, Meyer-Kornblum Marie, Kötschau Darja, Tennstedt Pierre, Huang Joseph, Gerhäuser Clarissa, Mader Malte, Kurtz Stefan, Sirma Hüseyin, Saad Fred, Steuber Thomas, Graefen Markus, Plass Christoph, Sauter Guido, Simon Ronald, Minner Sarah, Schlomm Thorsten

Abstract excerpt

The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is often altered in prostate cancer. To determine the prevalence and clinical significance of the different mechanisms of PTEN inactivation, we analyzed PTEN deletions in TMAs containing 4699 hormone-naïve and 57 hormone-refractory prostate cancers using fluorescence in situ hybridization analysis. PTEN mutations and methylation were analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22705054
DOI: 10.1016/j.ajpath.2012.04.026

Genes

PTEN
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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