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Article

PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer.

The Journal of pathology - 1 Aug 2009

Sircar Kanishka, Yoshimoto Maisa, Monzon Federico A, Koumakpayi Ismael H, Katz Ruth L, Khanna Abha, Alvarez Karla, Chen Guanyong, Darnel Andrew D, Aprikian Armen G, Saad Fred, Bismar Tarek A, Squire Jeremy A

Abstract excerpt

PTEN haploinsufficiency is common in hormone-sensitive prostate cancer, though the incidence of genomic deletion and its downstream effects have not been elucidated in clinical samples of hormone refractory prostate cancer (HRPC). Progression to androgen independence is pivotal in prostate cancer and mediated largely by the androgen receptor (AR). Since this process is distinct from metastatic progression, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19402094
DOI: 10.1002/path.2559

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer.PMID 19402094Read ↗

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PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancerSemantic proximity Read ↗

Is PTEN loss associated with clinical outcome measures in human prostate cancer?Semantic proximity Read ↗

PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer PatientsSemantic proximity Read ↗

The <i>PTEN</i> gene in locally progressive prostate cancer is preferentially inactivated by bi‐allelic gene deletionSemantic proximity Read ↗

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PTEN loss detection in prostate cancer: comparison of PTEN immunohistochemistry and PTEN FISH in a large retrospective prostatectomy cohortSemantic proximity Read ↗

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