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Article

<i>PTEN</i> genomic deletions that characterize aggressive prostate cancer originate close to segmental duplications

1 Nov 2011

Abstract excerpt

Deletion of PTEN at 10q23.3 occurs in ∼40% of human prostate cancers and is associated with aggressive metastatic potential, poor prognosis, and androgen-independence. This high frequency of recurrent PTEN deletions in prostate cancer suggests there may be unusual genomic features close to this locus that facilitate DNA alteration at 10q23.3. To explore possible mechanisms for deletions in the PTEN region, a...

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PMID: 22045666
DOI: 10.1002/gcc.20939

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<i>PTEN</i> genomic deletions that characterize aggressive prostate cancer originate close to segmental duplicationsPMID 22045666Read ↗

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