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Article

Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay.

PloS one - 1 Jan 2012

Rosains Jacqueline, Mango Susan E

Abstract excerpt

The nonsense mediated decay (NMD) pathway degrades mRNAs bearing premature translation termination codons. In mammals, SMG-8 has been implicated in the NMD pathway, in part by its association with SMG-1 kinase. Here we use four independent assays to show that C. elegans smg-8 is not required to degrade nonsense-containing mRNAs. We examine the genetic requirement for smg-8 to destabilize the endogenous, natural...

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Identifiers

PMID: 23166684
DOI: 10.1371/journal.pone.0049490
PMCID: PMC3500306

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