Article
Molecular identification of smg-4, required for mRNA surveillance in C. elegans.
Gene - 2 May 2001
Aronoff R, Baran R, Hodgkin J
Abstract excerpt
Premature termination codons trigger a process in eukaryotes known as nonsense mediated decay or mRNA surveillance, resulting in the rapid decay of the aberrant transcript. Studies in C. elegans have shown this system is mediated by seven smg genes and can prevent the accumulation of toxic, truncated peptides. Here we report the cloning of smg-4 by physical mapping and functional rescue assays. The minimal...
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