Article
A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans.
Science (New York, N.Y.) - 15 Sept 2000
Domeier M E, Morse D P, Knight S W, Portereiko M, Bass B L, Mango S E
Abstract excerpt
Double-stranded RNA (dsRNA) inhibits expression of homologous genes by a process involving messenger RNA degradation. To gain insight into the mechanism of degradation, we examined how RNA interference is affected by mutations in the smg genes, which are required for nonsense-mediated decay. For three of six smg genes tested, mutations resulted in animals that were initially silenced by dsRNA but then recovered;...
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