Article
RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans.
Nature communications - 9 Mar 2017
Son Heehwa G, Seo Mihwa, Ham Seokjin, Hwang Wooseon, Lee Dongyeop, An Seon Woo A, Artan Murat, Seo Keunhee, Kaletsky Rachel, Arey Rachel N, Ryu Youngjae, Ha Chang Man, Kim Yoon Ki, Murphy Coleen T, Roh Tae-Young, Nam Hong Gil, Lee Seung-Jae V
Abstract excerpt
Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Gene Expression Profiling
- Insulin
- Insulin-Like Growth Factor I
- Longevity
- Luminescent Proteins