mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans.

doi:10.1007/s004380050883

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Article

mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans.

Molecular & general genetics : MGG - 1 Nov 1998

Cali B M, Anderson P

Abstract excerpt

Nonsense mutant mRNAs are unstable in all eucaryotes tested, a phenomenon termed nonsense-mediated mRNA decay (NMD) or mRNA surveillance. Functions of the seven smg genes are required for mRNA surveillance in Caenorhabditis elegans. In Smg(+) genetic backgrounds, nonsense-mutant mRNAs are unstabl...

Topics

Animals
Caenorhabditis elegans
Gene Deletion
Gene Expression Regulation
Genes, Dominant
Genes, Lethal
Helminth Proteins
Male
Mutation
Myosin Heavy Chains
Phenotype
RNA, Messenger

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