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Article

mRNA surveillance by the Caenorhabditis elegans smg genes.

Genes & development - 1 Oct 1993

Pulak R, Anderson P

Abstract excerpt

mRNAs that contain premature stop codons are unstable in most eukaryotes, but the mechanism of their degradation is largely unknown. We demonstrate that functions of the six C. elegans smg genes are necessary for rapid turnover of nonsense mutant mRNAs of the unc-54 myosin heavy chain gene. Nonsense alleles of unc-54 express mRNAs that are unstable in smg(+) genetic backgrounds but have normal or near normal...

Topics

Animals
Caenorhabditis elegans
Frameshift Mutation
Genes, Dominant
Genes, Helminth
Genes, Recessive
Genes, Suppressor
Heterozygote
Muscles
Mutation
Myosins
Poly A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Processing, Post-Transcriptional

RNA, Messenger

Terminator Regions, Genetic

Source

Identifiers

PMID: 8104846
DOI: 10.1101/gad.7.10.1885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8104846-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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