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Article

Tet1 controls meiosis by regulating meiotic gene expression.

Nature - 20 Dec 2012

Yamaguchi Shinpei, Hong Kwonho, Liu Rui, Shen Li, Inoue Azusa, Diep Dinh, Zhang Kun, Zhang Yi

Abstract excerpt

Meiosis is a germ-cell-specific cell division process through which haploid gametes are produced for sexual reproduction. Before the initiation of meiosis, mouse primordial germ cells undergo a series of epigenetic reprogramming steps, including the global erasure of DNA methylation at the 5-position of cytosine (5mC) in CpG-rich DNA. Although several epigenetic regulators, such as Dnmt3l and the histone...

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Identifiers

PMID: 23151479
DOI: 10.1038/nature11709
PMCID: PMC3528851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tet1 controls meiosis by regulating meiotic gene expression.PMID 23151479Read ↗

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.Semantic proximity Read ↗

Role of Tet1 in erasure of genomic imprinting.Semantic proximity Read ↗

TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated RegionsSemantic proximity Read ↗

Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression programSemantic proximity Read ↗

Maternal TET3 is dispensable for embryonic development but is required for neonatal growthSemantic proximity Read ↗

Sex-specific exons control DNA methyltransferase in mammalian germ cellsSemantic proximity Read ↗

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosineSemantic proximity Read ↗

Tet1 Deficiency Leads to Premature Ovarian FailureSemantic proximity Read ↗

Roles of Tet2 in meiosis, fertility and reproductive agingSemantic proximity Read ↗

Imprinted gene dysregulation in a Tet1 null mouse model is stochastic and variable in the germline and offspringSemantic proximity Read ↗

Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.Semantic proximity Read ↗

TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in miceSemantic proximity Read ↗

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