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Article

Sex-specific exons control DNA methyltransferase in mammalian germ cells

1 Mar 1998

Abstract excerpt

The spermatozoon and oocyte genomes bear sex-specific methylation patterns that are established during gametogenesis and are required for the allele-specific expression of imprinted genes in somatic tissues. The mRNA for Dnmt1, the predominant maintenance and de novo DNA (cytosine-5)-methyl transferase in mammals, is present at high levels in postmitotic murine germ cells but undergoes alternative splicing of...

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PMID: 9449671
DOI: 10.1242/dev.125.5.889

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