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Article

Tet1 Deficiency Leads to Premature Ovarian Failure

23 Mar 2021

Abstract excerpt

Tet enzymes participate in DNA demethylation and play critical roles in stem cell pluripotency and differentiation. DNA methylation alters with age. We find that Tet1 deficiency reduces fertility and leads to accelerated reproductive failure with age. Noticeably, Tet1-deficient mice at young age exhibit dramatically reduced follicle reserve and the follicle reserve further decreases with age, phenomenon...

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Identifiers

PMID: 33834024
DOI: 10.3389/fcell.2021.644135

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