Roles of Tet2 in meiosis, fertility and reproductive aging

Abstract excerpt

Dear Editor, Ten-eleven translocation (Tet) enzymes play important roles in DNA demethylation involved in various biological processes including stem cell pluripotency and differentiation, and tumorigenesis (Dawlaty et al., 2013; Wu and Zhang, 2017). Tet2 deficiency or mutation leads to severe hematopoietic defects or myeloid malignancies in mice (Delhommeau et al., 2009; Ko et al., 2010; Moran-Crusio et al.,...

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