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Article

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.

Nature genetics - 1 Jun 2006

Smyth Deborah J, Cooper Jason D, Bailey Rebecca, Field Sarah, Burren Oliver, Smink Luc J, Guja Cristian, Ionescu-Tirgoviste Constantin, Widmer Barry, Dunger David B, Savage David A, Walker Neil M, Clayton David G, Todd John A

Abstract excerpt

In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard) on chromosome 2q24.3. We found the association in an interim analysis of a genome-wide nonsynonymous SNP (nsSNP) scan, and we validated it in a case-control collection and replicated it in an independent family collection. In...

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Share to Chromosomes, Human, Pair 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

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Share to Interferon-Induced Helicase, IFIH1

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Source

Identifiers

PMID: 16699517
DOI: 10.1038/ng1800

Genes

IFIH1

Variants

Provenance

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.PMID 16699517Read ↗

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