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Article

A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencing.

PloS one - 1 Jan 2012

Mijušković Martina, Brown Stuart M, Tang Zuojian, Lindsay Cory R, Efstathiadis Efstratios, Deriano Ludovic, Roth David B

Abstract excerpt

Defining the architecture of a specific cancer genome, including its structural variants, is essential for understanding tumor biology, mechanisms of oncogenesis, and for designing effective personalized therapies. Short read paired-end sequencing is currently the most sensitive method for detecting somatic mutations that arise during tumor development. However, mapping structural variants using this method leads...

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Identifiers

PMID: 23144753
DOI: 10.1371/journal.pone.0048314
PMCID: PMC3483208

Genes

RAG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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