Article

Severus: accurate detection and characterization of somatic structural variation in tumor genomes using long reads

2024-03-26

Abstract excerpt

Most current studies rely on short-read sequencing to detect somatic structural variation (SV) in cancer genomes. Long-read sequencing offers the advantage of better mappability and long-range phasing, which results in substantial improvements in germline SV detection. However, current long-read SV detection methods do not generalize well to the analysis of somatic SVs in tumor genomes with complex rearrangements,...

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Literature Corpus work: f0a5593d-4ec7-5c49-91b2-bf62ad305dbc
DOI: 10.1101/2024.03.22.24304756

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