Article
Identification of medium-sized genomic deletions with low coverage, mate-paired restricted tags.
BMC genomics - 24 Jan 2013
Gong Qiang, Tao Yong, Yang Jian-Rong, Cai Jun, Yuan Yunfei, Ruan Jue, Yang Jin, Liu Hailiang, Li Wanghua, Lu Xuemei, Zhuang Shi-Mei, Wang San Ming, Wu Chung-I
Abstract excerpt
BACKGROUND: Genomic deletions are known to be widespread in many species. Variant sequencing-based approaches for identifying deletions have been developed, but their powers to detect those deletions that affect medium-sized regions are limited when the sequencing coverage is low. RESULTS: We present a cost-effective method for identifying medium-sized deletions in genomic regions with low genomic coverage. Two...
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