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Article

COSMOS: accurate detection of somatic structural variations through asymmetric comparison between tumor and normal samples.

Nucleic acids research - 5 May 2016

Yamagata Koichi, Yamanishi Ayako, Kokubu Chikara, Takeda Junji, Sese Jun

Abstract excerpt

An important challenge in cancer genomics is precise detection of structural variations (SVs) by high-throughput short-read sequencing, which is hampered by the high false discovery rates of existing analysis tools. Here, we propose an accurate SV detection method named COSMOS, which compares the statistics of the mapped read pairs in tumor samples with isogenic normal control samples in a distinct asymmetric...

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Identifiers

PMID: 26833260
DOI: 10.1093/nar/gkw026
PMCID: PMC4856976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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