Article
Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor.
The Journal of biological chemistry - 4 Jan 2013
Unal Hamiyet, Jagannathan Rajaganapathi, Bhatnagar Anushree, Tirupula Kalyan, Desnoyer Russell, Karnik Sadashiva S
Abstract excerpt
The topology of the second extracellular loop (ECL2) and its interaction with ligands is unique in each G protein-coupled receptor. When the orthosteric ligand pocket located in the transmembrane (TM) domain is occupied, ligand-specific conformational changes occur in the ECL2. In more than 90% of G protein-coupled receptors, ECL2 is tethered to the third TM helix via a disulfide bond. Therefore, understanding...
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