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Article

Allosteric interactions within the AT₁ angiotensin receptor homodimer: role of the conserved DRY motif.

Biochemical pharmacology - 15 Aug 2012

Szalai Bence, Barkai László, Turu Gábor, Szidonya László, Várnai Péter, Hunyady László

Abstract excerpt

G protein coupled receptor (GPCR) dimerization has a remarkable impact on the diversity of receptor signaling. Allosteric communication between the protomers of the dimer can alter ligand binding, receptor conformation and interactions with different effector proteins. In this study we investigated the allosteric interactions between wild type and mutant protomers of type 1 angiotensin receptor (AT₁R) dimers...

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Source

Identifiers

PMID: 22579851
DOI: 10.1016/j.bcp.2012.04.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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