Article
Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.
Molecular and cellular endocrinology - 15 Oct 2017
Woolley Michael J, Simms John, Mobarec Juan Carlos, Reynolds Christopher A, Poyner David R, Conner Alex C
Abstract excerpt
The extracellular loop 2 (ECL2) region is the most conserved of the three ECL domains in family B G protein-coupled receptors (GPCRs) and has a fundamental role in ligand binding and activation across the receptor super-family. ECL2 is fundamental for ligand-induced activation of the calcitonin gene related peptide (CGRP) receptor, a family B GPCR implicated in migraine and heart disease. In this study we apply a...
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