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Article

Critical hydrogen bond formation for activation of the angiotensin II type 1 receptor.

The Journal of biological chemistry - 25 Jan 2013

Cabana Jérôme, Holleran Brian, Beaulieu Marie-Ève, Leduc Richard, Escher Emanuel, Guillemette Gaétan, Lavigne Pierre

Abstract excerpt

G protein-coupled receptors contain selectively important residues that play central roles in the conformational changes that occur during receptor activation. Asparagine 111 (N111(3.35)) is such a residue within the angiotensin II type 1 (AT(1)) receptor. Substitution of N111(3.35) for glycine leads to a constitutively active receptor, whereas substitution for tryptophan leads to an inactivable receptor. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Angiotensin, Type 1

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Identifiers

PMID: 23223579
DOI: 10.1074/jbc.M112.395939
PMCID: PMC3554926

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