Structural basis for selectivity and diversity in angiotensin II receptors.

doi:10.1038/nature22035

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Article

Structural basis for selectivity and diversity in angiotensin II receptors.

Nature - 20 Apr 2017

Zhang Haitao, Han Gye Won, Batyuk Alexander, Ishchenko Andrii, White Kate L, Patel Nilkanth, Sadybekov Anastasiia, Zamlynny Beata, Rudd Michael T, Hollenstein Kaspar, Tolstikova Alexandra, White Thomas A, Hunter Mark S, Weierstall Uwe, Liu Wei, Babaoglu Kerim, Moore Eric L, Katz Ryan D, Shipman Jennifer M, Garcia-Calvo Margarita, Sharma Sujata, Sheth Payal, Soisson Stephen M, Stevens Raymond C, Katritch Vsevolod, Cherezov Vadim

Abstract excerpt

The angiotensin II receptors AT1R and AT2R serve as key components of the renin-angiotensin-aldosterone system. AT1R has a central role in the regulation of blood pressure, but the function of AT2R is unclear and it has a variety of reported effects. To identify the mechanisms that underlie the differences in function and ligand selectivity between these receptors, here we report crystal structures of human AT2R...

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PMID: 28379944
DOI: 10.1038/nature22035
PMCID: PMC5525545

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