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Article

Dynamics of the Second Extracellular Loop Control Transducer Coupling of Peptide-Activated GPCRs.

International journal of molecular sciences - 30 Jul 2023

Wygas Marcel M, Laugwitz Jeannette M, Schmidt Peter, Elgeti Matthias, Kaiser Anette

Abstract excerpt

Many peptide-activated rhodopsin-like GPCRs share a β-hairpin folding motif in the extracellular loop 2 (ECL2), which interacts with the peptide ligand while at the same time being connected to transmembrane helix 3 (TM3) via a highly conserved disulfide bond. Currently, it remains unknown whether the coupling of the specifically shaped ECL2 to TM3 influences the activation of peptide-activated GPCRs. We...

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Identifiers

PMID: 37569573
DOI: 10.3390/ijms241512197
PMCID: PMC10419011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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