Article
Activation induces structural changes in the liganded angiotensin II type 1 receptor.
The Journal of biological chemistry - 25 Sept 2009
Clément Martin, Cabana Jérôme, Holleran Brian J, Leduc Richard, Guillemette Gaétan, Lavigne Pierre, Escher Emanuel
Abstract excerpt
The octapeptide hormone angiotensin II (AngII) binds to and activates the human angiotensin II type 1 receptor (hAT(1)) of the G protein-coupled receptor class A family. Several activation mechanisms have been proposed for this family, but they have not yet been experimentally validated. We previ...
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