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Article

Molecular mechanisms of constitutive activity: mutations at position 111 of the angiotensin AT1 receptor.

The journal of peptide research : official journal of the American Peptide Society - 1 Nov 2005

Nikiforovich G V, Mihalik B, Catt K J, Marshall G R

Abstract excerpt

A possible molecular mechanism for the constitutive activity of mutants of the angiotensin type 1 receptor (AT1) at position 111 was suggested by molecular modeling. This involves a cascade of conformational changes in spatial positions of side chains along transmembrane helix (TM3) from L112 to Y113 to F117, which in turn, results in conformational changes in TM4 (residues I152 and M155) leading to the movement...

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PMID: 16218991
DOI: 10.1111/j.1399-3011.2005.00293.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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