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Article

Constitutive activity in the angiotensin II type 1 receptor: discovery and applications.

Advances in pharmacology (San Diego, Calif.) - 1 Jan 2014

Unal Hamiyet, Karnik Sadashiva S

Abstract excerpt

The pathophysiological actions of the renin-angiotensin system hormone, angiotensin II (AngII), are mainly mediated by the AngII type 1 (AT1) receptor, a GPCR. The intrinsic spontaneous activity of the AT1 receptor in native tissues is difficult to detect due to its low expression levels. However, factors such as the membrane environment, interaction with autoantibodies, and mechanical stretch are known to...

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Topics

Animals
Biomedical Research
Drug Discovery
Drug Inverse Agonism
Humans
Mutation
Receptor, Angiotensin, Type 1

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Identifiers

PMID: 24931196
DOI: 10.1016/B978-0-12-417197-8.00006-7
PMCID: PMC7500102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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