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Article

Fingerloop activates cargo delivery and unloading during cotranslational protein targeting.

Molecular biology of the cell - 1 Jan 2013

Ariosa Aileen R, Duncan Stacy S, Saraogi Ishu, Lu Xiaodong, Brown April, Phillips Gregory J, Shan Shu-Ou

Abstract excerpt

During cotranslational protein targeting by the signal recognition particle (SRP), information about signal sequence binding in the SRP's M domain must be effectively communicated to its GTPase domain to turn on its interaction with the SRP receptor (SR) and thus deliver the cargo proteins to the membrane. A universally conserved "fingerloop" lines the signal sequence-binding groove of SRP; the precise role of...

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Identifiers

PMID: 23135999
DOI: 10.1091/mbc.E12-06-0434
PMCID: PMC3541965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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