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Article

SecA mediates cotranslational targeting and translocation of an inner membrane protein.

The Journal of cell biology - 6 Nov 2017

Wang Shuai, Yang Chien-I, Shan Shu-Ou

Abstract excerpt

Protein targeting to the bacterial plasma membrane was generally thought to occur via two major pathways: cotranslational targeting by signal recognition particle (SRP) and posttranslational targeting by SecA and SecB. Recently, SecA was found to also bind ribosomes near the nascent polypeptide exit tunnel, but the function of this SecA-ribosome contact remains unclear. In this study, we show that SecA...

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Source

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Identifiers

PMID: 28928132
DOI: 10.1083/jcb.201704036
PMCID: PMC5674894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SecA mediates cotranslational targeting and translocation of an inner membrane protein.PMID 28928132Read ↗

SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein.Semantic proximity Read ↗

Dynamic action of the Sec machinery during initiation, protein translocation and termination.Semantic proximity Read ↗

The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins.Semantic proximity Read ↗

Membrane protein sequence features direct post-translational insertionSemantic proximity Read ↗

The SecY translocation complex: convergence of genetics and structure.Semantic proximity Read ↗

SecA is required for the insertion of inner membrane proteins targeted by the Escherichia coli signal recognition particle.Semantic proximity Read ↗

Features of membrane protein sequence direct post-translational insertion.Semantic proximity Read ↗

Structural insights into the mechanism of a novel protein targeting pathway in Gram-negative bacteria.Semantic proximity Read ↗

Trigger factor is a bona fide secretory pathway chaperone that interacts with SecB and the translocaseSemantic proximity Read ↗

SecA interacts with ribosomes in order to facilitate posttranslational translocation in bacteria.Semantic proximity Read ↗

Diversity and evolution of protein translocation.Semantic proximity Read ↗

Competition between Sec- and TAT-dependent protein translocation in Escherichia coli.Semantic proximity Read ↗

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