A new targeting motif for endoplasmic reticulum surface proteins

Abstract excerpt

The Endoplasmic Reticulum (ER) is the entry site to the secretory pathway, serving as the targeting destination for ∼30% of the proteome. The mechanisms for targeting soluble or integral membrane secretory pathway proteins are well-studied. However, it is currently unknown how the tens of ER surface proteins (SuPs), central for organelle function, reach the outer leaflet of the membrane. It was previously shown th...

Topics

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• Amino Acids, Aromatic
• Endoplasmic Reticulum
• Molecular Weight
• Protein Engineering
• Protein Interaction Domains and Motifs
• Receptors, Cytoplasmic and Nuclear
• Receptors, Peptide
• Two-Hybrid System Techniques

Identifiers and source

Literature Corpus work

afae85f8-7271-53bb-80ae-7d77efed4fab

DOI

10.1101/2024.04.22.590521