Article
Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end.
The Journal of biological chemistry - 20 Dec 2013
Shen Kuang, Wang Yaqiang, Hwang Fu Yu-Hsien, Zhang Qi, Feigon Juli, Shan Shu-ou
Abstract excerpt
The signal recognition particle (SRP) RNA is a universally conserved and essential component of the SRP that mediates the co-translational targeting of proteins to the correct cellular membrane. During the targeting reaction, two functional ends in the SRP RNA mediate distinct functions. Whereas the RNA tetraloop facilitates initial assembly of two GTPases between the SRP and SRP receptor, this GTPase complex...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Escherichia coli
- Escherichia coli Proteins
- GTP Phosphohydrolases
- Molecular Docking Simulation
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Binding
- RNA, Small Cytoplasmic
- Receptors, Cytoplasmic and Nuclear