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Article

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2010

Shen Kuang, Shan Shu-ou

Abstract excerpt

Kinetic control of macromolecular interactions plays key roles in biological regulation. An example of such control occurs in cotranslational protein targeting by the signal recognition particle (SRP), during which the SRP RNA and the cargo both accelerate complex assembly between the SRP and SRP receptor FtsY 10(2)-fold. The molecular mechanism underlying these rate accelerations was unclear. Here we show that a...

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Identifiers

PMID: 20385832
DOI: 10.1073/pnas.1002968107
PMCID: PMC2867919

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