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Article

Mechanism of association and reciprocal activation of two GTPases.

PLoS biology - 1 Oct 2004

Shan Shu-ou, Stroud Robert M, Walter Peter

Abstract excerpt

The signal recognition particle (SRP) mediates the cotranslational targeting of nascent proteins to the eukaryotic endoplasmic reticulum membrane or the bacterial plasma membrane. During this process, two GTPases, one in SRP and one in the SRP receptor (named Ffh and FtsY in bacteria, respectively), form a complex in which both proteins reciprocally activate the GTPase reaction of one another. Here, we explore by...

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Identifiers

PMID: 15383838
DOI: 10.1371/journal.pbio.0020320
PMCID: PMC517823

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Source receipt: pubmed, retrieved 7 Sept 2026.

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