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Article

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.

RNA (New York, N.Y.) - 1 Feb 2007

Siu Fai Y, Spanggord Richard J, Doudna Jennifer A

Abstract excerpt

The signal recognition particle (SRP) cotranslationally targets proteins to cell membranes by coordinated binding and release of ribosome-associated nascent polypeptides and a membrane-associated SRP receptor. GTP uptake and hydrolysis by the SRP-receptor complex govern this targeting cycle. Because no GTPase-activating proteins (GAPs) are known for the SRP and SRP receptor GTPases, however, it has been unclear...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17164479
DOI: 10.1261/rna.135407
PMCID: PMC1781372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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