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Article

Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin.

Molecular biology of the cell - 1 Jan 2013

Chaudhry Faisal, Breitsprecher Dennis, Little Kristin, Sharov Grigory, Sokolova Olga, Goode Bruce L

Abstract excerpt

Actin filament severing is critical for the dynamic turnover of cellular actin networks. Cofilin severs filaments, but additional factors may be required to increase severing efficiency in vivo. Srv2/cyclase-associated protein (CAP) is a widely expressed protein with a role in binding and recycling actin monomers ascribed to domains in its C-terminus (C-Srv2). In this paper, we report a new biochemical and...

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Identifiers

PMID: 23135996
DOI: 10.1091/mbc.E12-08-0589
PMCID: PMC3530777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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