Article
Structural implications of Ca2+-dependent actin-bundling function of human EFhd2/Swiprosin-1.
Scientific reports - 15 Dec 2016
Park Kyoung Ryoung, Kwon Min-Sung, An Jun Yop, Lee Jung-Gyu, Youn Hyung-Seop, Lee Youngjin, Kang Jung Youn, Kim Tae Gyun, Lim Jia Jia, Park Jeong Soon, Lee Sung Haeng, Song Woo Keun, Cheong Hae-Kap, Jun Chang-Duk, Eom Soo Hyun
Abstract excerpt
EFhd2/Swiprosin-1 is a cytoskeletal Ca2+-binding protein implicated in Ca2+-dependent cell spreading and migration in epithelial cells. EFhd2 domain architecture includes an N-terminal disordered region, a PxxP motif, two EF-hands, a ligand mimic helix and a C-terminal coiled-coil domain. We reported previously that EFhd2 displays F-actin bundling activity in the presence of Ca2+ and this activity depends on the...
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