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Article

The actin-severing activity of cofilin is exerted by the interplay of three distinct sites on cofilin and essential for cell viability.

The Biochemical journal - 1 Jul 2002

Moriyama Kenji, Yahara Ichiro

Abstract excerpt

Cofilin/actin-depolymerizing factor is an essential and conserved modulator of actin dynamics. Cofilin binds to actin in either monomeric or filamentous form, severs and depolymerizes actin filaments, and speeds up their treadmilling. A high turnover rate of F-actin in actin-based motility seems driven largely by cofilin-mediated acceleration of directional subunit release, but little by fragmentation of the...

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Identifiers

PMID: 12113256
DOI: 10.1042/bj20020231
PMCID: PMC1222676

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Source receipt: pubmed, retrieved 7 Sept 2026.

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