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Article

Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks.

Nature cell biology - 1 Feb 2021

Hakala Markku, Wioland Hugo, Tolonen Mari, Kotila Tommi, Jegou Antoine, Romet-Lemonne Guillaume, Lappalainen Pekka

Abstract excerpt

Coordinated polymerization of actin filaments provides force for cell migration, morphogenesis and endocytosis. Capping protein (CP) is a central regulator of actin dynamics in all eukaryotes. It binds to actin filament (F-actin) barbed ends with high affinity and slow dissociation kinetics to prevent filament polymerization and depolymerization. However, in cells, CP displays remarkably rapid dynamics within...

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PMID: 33558729
DOI: 10.1038/s41556-020-00629-y

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CP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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