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Article

A cytoskeletal localizing domain in the cyclase-associated protein, CAP/Srv2p, regulates access to a distant SH3-binding site.

The Journal of biological chemistry - 9 Jul 1999

Yu J, Wang C, Palmieri S J, Haarer B K, Field J

Abstract excerpt

In the yeast, Saccharomyces cerevisiae, adenylyl cyclase consists of a 200-kDa catalytic subunit (CYR1) and a 70-kDa subunit (CAP/SRV2). CAP/Srv2p assists the small G protein Ras to activate adenylyl cyclase. CAP also regulates the cytoskeleton through an actin sequestering activity and is directed to cortical actin patches by a proline-rich SH3-binding site (P2). In this report we analyze the role of the actin...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10391948
DOI: 10.1074/jbc.274.28.19985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A cytoskeletal localizing domain in the cyclase-associated protein, CAP/Srv2p, regulates access to a distant SH3-binding site.PMID 10391948Read ↗

A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein.Semantic proximity Read ↗

Association of elongation factor 1 alpha and ribosomal protein L3 with the proline-rich region of yeast adenylyl cyclase-associated protein CAP.Semantic proximity Read ↗

Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein.Semantic proximity Read ↗

SRV2, a gene required for RAS activation of adenylate cyclase in yeast.Semantic proximity Read ↗

Actin-induced hyperactivation of the Ras signaling pathway leads to apoptosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Disease association of cyclase-associated protein (CAP): Lessons from gene-targeted mice and human genetic studiesSemantic proximity Read ↗

Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin.Semantic proximity Read ↗

Evidence for physical and functional interactions among two Saccharomyces cerevisiae SH3 domain proteins, an adenylyl cyclase-associated protein and the actin cytoskeleton.Semantic proximity Read ↗

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Coiled-coil interaction of N-terminal 36 residues of cyclase-associated protein with adenylyl cyclase is sufficient for its function in Saccharomyces cerevisiae ras pathway.Semantic proximity Read ↗

Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activation.Semantic proximity Read ↗

Disruption of the actin cytoskeleton in yeast capping protein mutants.Semantic proximity Read ↗

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