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Article

Aip1 promotes actin filament severing by cofilin and regulates constriction of the cytokinetic contractile ring.

The Journal of biological chemistry - 23 Jan 2015

Chen Qian, Courtemanche Naomi, Pollard Thomas D

Abstract excerpt

Aip1 (actin interacting protein 1) is ubiquitous in eukaryotic organisms, where it cooperates with cofilin to disassemble actin filaments, but neither its mechanism of action nor its biological functions have been clear. We purified both fission yeast and human Aip1 and investigated their biochemical activities with or without cofilin. Both types of Aip1 bind actin filaments with micromolar affinities and weakly...

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Identifiers

PMID: 25451933
DOI: 10.1074/jbc.M114.612978
PMCID: PMC4303679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aip1 promotes actin filament severing by cofilin and regulates constriction of the cytokinetic contractile ring.PMID 25451933Read ↗

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