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Article

CAS-1, a C. elegans cyclase-associated protein, is required for sarcomeric actin assembly in striated muscle.

Journal of cell science - 1 Sept 2012

Nomura Kazumi, Ono Kanako, Ono Shoichiro

Abstract excerpt

Assembly of contractile apparatuses in striated muscle requires precisely regulated reorganization of the actin cytoskeletal proteins into sarcomeric organization. Regulation of actin filament dynamics is one of the essential processes of myofibril assembly, but the mechanism of actin regulation in striated muscle is not clearly understood. Actin depolymerizing factor (ADF)/cofilin is a key enhancer of actin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22623720
DOI: 10.1242/jcs.104950
PMCID: PMC3482317

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Related research

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CAS-1, a C. elegans cyclase-associated protein, is required for sarcomeric actin assembly in striated muscle.PMID 22623720Read ↗

Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle.Semantic proximity Read ↗

The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments.Semantic proximity Read ↗

Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform.Semantic proximity Read ↗

Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.Semantic proximity Read ↗

A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein.Semantic proximity Read ↗

The two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegans.Semantic proximity Read ↗

Disease association of cyclase-associated protein (CAP): Lessons from gene-targeted mice and human genetic studiesSemantic proximity Read ↗

Enhancement of actin-depolymerizing factor/cofilin-dependent actin disassembly by actin-interacting protein 1 is required for organized actin filament assembly in the Caenorhabditis elegans body wall muscle.Semantic proximity Read ↗

Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin.Semantic proximity Read ↗

The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.Semantic proximity Read ↗

Mutations in Caenorhabditis elegans actin, which are equivalent to human cardiomyopathy mutations, cause abnormal actin aggregation in nematode striated muscleSemantic proximity Read ↗

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