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Article

Mechanism and biological role of profilin-Srv2/CAP interaction.

Journal of cell science - 1 Apr 2007

Bertling Enni, Quintero-Monzon Omar, Mattila Pieta K, Goode Bruce L, Lappalainen Pekka

Abstract excerpt

Profilin and cyclase-associated protein (CAP, known in yeast as Srv2) are ubiquitous and abundant actin monomer-binding proteins. Profilin catalyses the nucleotide exchange on actin monomers and promotes their addition to filament barbed ends. Srv2/CAP recycles newly depolymerized actin monomers from ADF/cofilin for subsequent rounds of polymerization. Srv2/CAP also harbors two proline-rich motifs and has been...

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Source

Identifiers

PMID: 17376963
DOI: 10.1242/jcs.000158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism and biological role of profilin-Srv2/CAP interaction.PMID 17376963Read ↗

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A cytoskeletal localizing domain in the cyclase-associated protein, CAP/Srv2p, regulates access to a distant SH3-binding site.Semantic proximity Read ↗

Mutational analysis of yeast profilin.Semantic proximity Read ↗

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Association of elongation factor 1 alpha and ribosomal protein L3 with the proline-rich region of yeast adenylyl cyclase-associated protein CAP.Semantic proximity Read ↗

Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.Semantic proximity Read ↗

Profilin binding to poly-L-proline and actin monomers along with ability to catalyze actin nucleotide exchange is required for viability of fission yeast.Semantic proximity Read ↗

SRV2, a gene required for RAS activation of adenylate cyclase in yeast.Semantic proximity Read ↗

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High-speed depolymerization at actin filament ends jointly catalysed by Twinfilin and Srv2/CAP.Semantic proximity Read ↗

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