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Article

Comparative quantitative analysis of hepatitis C mutations at amino acids 70 and 91 in the core region by the Q-Invader assay.

Journal of virological methods - 1 Apr 2013

Tadokoro Kenichi, Kobayashi Mariko, Suzuki Fumitaka, Tanaka Chie, Yamaguchi Toshikazu, Nagano Makoto, Egashira Toru, Kumada Hiromitsu

Abstract excerpt

Hepatitis C virus (HCV) is a major worldwide public health problem, and mutations at amino acids 70 and 91 in the genotype 1b core region predict the effectiveness of combination therapy with peginterferon and ribavirin. An assay based on the Q-Invader technology was developed to determine the relative ratios of the mutant to wild-type virus with high sensitivity. The assay detected a minor type plasmid that...

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PMID: 23124003
DOI: 10.1016/j.jviromet.2012.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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