Article
Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay.
PloS one - 1 Jan 2015
Yoshimi Satoshi, Ochi Hidenori, Murakami Eisuke, Uchida Takuro, Kan Hiromi, Akamatsu Sakura, Hayes C Nelson, Abe Hiromi, Miki Daiki, Hiraga Nobuhiko, Imamura Michio, Aikata Hiroshi, Chayama Kazuaki
Abstract excerpt
Daclatasvir and asunaprevir dual oral therapy is expected to achieve high sustained virological response (SVR) rates in patients with HCV genotype 1b infection. However, presence of the NS5A-Y93H substitution at baseline has been shown to be an independent predictor of treatment failure for this regimen. By using the Invader assay, we developed a system to rapidly and accurately detect the presence of mutant...
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