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Article

[Construction and sequence analysis of recombinant HCV-1b replicon by replacing NS5A region].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 1 Jan 2012

Li Jingtao, Zhou Bin, Zhou Yuanping, Zeng Yanli, Li Wei, Wang Junjie, Zhang Jian, Zhang Hao, Liu Shuwen

Abstract excerpt

OBJECTIVE: To construct the recombinant HCV-1b replicon by replacing NS5A region using serum samples from patients with chronic hepatitis C (CHC) in South China and explore the biological characteristics of NS5A protein in response to antiviral therapy. METHODS: The on-off plasmid containing the cutting sites of the restriction endonucleases MIu I and Bcl I was designed based on the backbone of robust HCV 1b...

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PMID: 22366003

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