Article
Comparison of direct sequencing and Invader assay for Y93H mutation and response to interferon-free therapy in hepatitis C virus genotype 1b.
Journal of gastroenterology and hepatology - 1 Jan 2018
Hayashi Kazuhiko, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Kawashima Hiroki, Ishikawa Tetsuya, Tachi Yoshihiko, Hattori Masashi, Katano Yoshiaki, Goto Hidemi, Hirooka Yoshiki
Abstract excerpt
BACKGROUND AND AIM: Virologic failure of interferon-free therapy has been associated with Y93H mutation in the non-structure 5A region in hepatitis C virus (HCV) genotype 1b, and screening is recommended. A simple assay based on Q-Invader technology was developed for Y93H mutant screening to reduce cost and effort. The present study sought to compare two methods of detection of Y93H mutation and to evaluate the...
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