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Article

Impact of Mutations at Amino Acid 70 in Hepatitis C Virus (HCV) Genotype 1b Core Region on Hepatocarcinogenesis following Eradication of HCV RNA.

Journal of clinical microbiology - 1 Sept 2015

Akuta Norio, Suzuki Fumitaka, Kobayashi Masahiro, Sezaki Hitomi, Kawamura Yusuke, Hosaka Tetsuya, Kobayashi Mariko, Saitoh Satoshi, Suzuki Yoshiyuki, Arase Yasuji, Ikeda Kenji, Kumada Hiromitsu

Abstract excerpt

The impact of the HCV genotype 1b core amino acid (aa) 70 mutant on the cumulative rate of hepatocellular carcinoma following eradication of HCV RNA by antiviral therapy was investigated with the Q-Invader assay. Multivariate analysis based on 649 patients indicated that a core aa70 Q-Invader mutant level ≥20% is a predictor of hepatocellular carcinoma.

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Share to Antiviral Agents
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Liver Neoplasms

Share to Mutation, Missense

Share to RNA, Viral

Share to Viral Core Proteins

Source

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Identifiers

PMID: 26135874
DOI: 10.1128/JCM.01457-15
PMCID: PMC4540910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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