Article
Quantification of hepatitis C amino acid substitutions 70 and 91 in the core coding region by real-time amplification refractory mutation system reverse transcription-polymerase chain reaction.
Scandinavian journal of gastroenterology - 1 Jan 2009
Nakamoto Shingo, Kanda Tatsuo, Yonemitsu Yutaka, Arai Makoto, Fujiwara Keiichi, Fukai Kenichi, Kanai Fumihiko, Imazeki Fumio, Yokosuka Osamu
Abstract excerpt
OBJECTIVE: The effects of hepatitis C virus (HCV) sequence variations on the success of antiviral therapy or the development of hepatocellular carcinoma (HCC) are complex for many reasons. Recently, there have been several reports on the effects of genotype 1b HCV core amino acid substitutions 70 and/or 91 on the outcome of antiviral therapies and the clinical course. The purpose of this study was to establish...
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